C-terminal tripeptide of alpha-MSH with potent anti-inflammatory properties, especially for gut health.
Activates MC1R and MC3R receptors, inhibiting NF-ÎșB signaling and reducing pro-inflammatory cytokine production (TNF-α, IL-6, IL-1ÎČ). Works locally in the gut when taken orally, surviving gastric acid to some extent.
The C-terminal tripeptide (Lys-Pro-Val) of α-MSH retains most of the anti-inflammatory activity of the full peptide. This makes it a more accessible and targeted option for gut inflammation research.
Can be taken orally for gut-specific effects â one of the few peptides with meaningful oral bioavailability for its target tissue. This is because the gut mucosa is its primary target and it can act before being fully broken down.