Melanocortin agonist derived from Melanotan II, researched for sexual dysfunction.
Primarily acts on MC4R in the central nervous system to increase sexual arousal independent of hormonal pathways. Unlike PDE5 inhibitors, works through the brain rather than vascular mechanisms, making it effective for both men and women.
FDA-approved as Vyleesi (1.75mg nasal spray) for hypoactive sexual desire disorder in premenopausal women. One of the few peptides with CNS-mediated mechanism for sexual function.
Unlike Viagra/Cialis which require sexual stimulation and work via nitric oxide, PT-141 activates desire and arousal centrally. This makes it potentially useful for disorders where the issue is desire rather than physical performance.