Synthetic ACTH analogue developed in Russia — nootropic with BDNF-stimulating and neuroprotective properties.
Increases BDNF and NGF expression, enhancing neuroplasticity and synaptogenesis. Modulates dopaminergic and serotonergic systems. Has antioxidant and neuroprotective effects against ischemic damage and oxidative stress.
Developed by the Institute of Molecular Genetics in Russia. Approved in Russia for stroke treatment and cognitive disorders. The N-acetyl version (N-Acetyl Semax Amidate) has longer action and is considered more potent.
Often administered intranasally for CNS delivery, bypassing the blood-brain barrier. Some researchers prefer SubQ for more consistent dosing. The active metabolites have longer half-lives than the parent compound.