First 29 amino acids of natural GHRH — stimulates the pituitary to produce its own GH.
Binds to GHRH receptors in the anterior pituitary, stimulating natural GH synthesis and secretion in a pulsatile manner. Works through the body's own feedback mechanisms, preserving the natural GH axis.
FDA-approved (as Geref) for GH deficiency diagnosis. Short half-life requires daily administration. Considered more natural than synthetic GH because it works through the pituitary's own production mechanisms.
Because Sermorelin works through the natural GH axis, it is subject to the body's normal feedback regulation — it cannot cause supraphysiological GH levels the way exogenous HGH can.