An NNMT inhibitor that raises NAD+ precursors and drives fat reduction via metabolic reprogramming.
Inhibits Nicotinamide N-methyltransferase (NNMT) — an enzyme that consumes SAM (S-adenosylmethionine) and converts nicotinamide to 1-methylnicotinamide. By inhibiting NNMT, 5-Amino-1MQ raises SAM levels, increases the NAD+ precursor pool, boosts mitochondrial activity, and drives fat loss through metabolic reprogramming in adipose tissue.
Published research from Cornell University demonstrated that 5-Amino-1MQ prevented diet-induced obesity in mice on high-fat diets and reduced adipocyte size without caloric restriction. The effect was driven primarily by NNMT inhibition in fat tissue.
Unlike direct NAD+ precursors (NR, NMN), 5-Amino-1MQ raises NAD+ indirectly by blocking its metabolic consumption. This distinguishes it mechanistically from other NAD+ support compounds.