A GHRH analogue with a 30-minute half-life, typically paired with a GHRP to create synergistic pulsatile GH release.
Binds pituitary GHRH receptors to stimulate growth hormone secretion. The short half-life without DAC mirrors the natural GHRH pulse and must be dosed multiple times daily or combined with a GHRP (e.g., Ipamorelin) to amplify GH release at the pituitary. The combination acts on complementary receptors for synergistic output.
CJC-1295 without DAC is also called Modified GRF 1-29 (Mod GRF). The 'no DAC' designation distinguishes it from CJC-1295 with Drug Affinity Complex, which has a much longer half-life.
Most protocols pair Mod GRF with Ipamorelin or another GHRP in a 1:1 ratio, administered before sleep or after training to leverage the synergistic GH pulse with minimal cortisol or prolactin elevation.